Correction for Kim et al., Contribution of teg49 Small RNA in the 5' Upstream Transcriptional Region of sarA to Virulence in Staphylococcus aureus.
نویسندگان
چکیده
Samin Kim, Dindo Reyes, Marie Beaume, Patrice Francois, Ambrose Cheung Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; Service of Infectious Diseases, Geneva University Hospitals and Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland; Genomic Research Lab, Services of Infectious Diseases, Geneva University Hospital, Geneva, Switzerland
منابع مشابه
Contribution of teg49 small RNA in the 5' upstream transcriptional region of sarA to virulence in Staphylococcus aureus.
High-throughput RNA sequencing technology has found the 5' untranslated region of sarA to contain two putative small RNAs (sRNAs), designated teg49 and teg48. Northern blot analysis disclosed that teg49 and teg48 were detectable within the P3-P1 and P1 sarA promoter regions, respectively. Focusing on teg49, we found that this sRNA, consisting of 196 nucleotides, is transcribed in the same direc...
متن کاملAntibacterial activity of silver nanoparticles target sara through srna-teg49, a key mediator of hfq, in staphylococcus aureus.
UNLABELLED Attributed to its antimicrobial effect, Silver nanoparticles (AgNPs) is widely used in various fields, such as biomedicine, textiles, health care products and food, etc. However, the antibacterial mechanism of AgNPs in staphylococcus aureus (S. aureus) by regulating sRNA expression remains largely unknown. OBJECTIVES This study was performed to investigate the involvement of the an...
متن کاملTranscriptional analysis of different promoters in the sar locus in Staphylococcus aureus.
The expression of extracellular virulence determinants in Staphylococcus aureus is controlled by a 510-nucleotide RNA molecule (RNAIII) which is a part of the agr system. The agr operon, which encodes a multicomponent signal transduction system, is partially under the influence of an unlinked regulatory locus called sar. The sar locus is composed of three overlapping transcripts, designated sar...
متن کاملExpression of SarX, a negative regulator of agr and exoprotein synthesis, is activated by MgrA in Staphylococcus aureus.
The expression of genes involved in the pathogenesis of Staphylococcus aureus is known to be controlled by global regulatory loci, including agr, sarA, saeRS, arlRS, and sarA-like genes. As part of our continuing efforts to understand the regulatory mechanisms that involve sarA-like genes, we describe here the characterization of a novel transcriptional regulator called SarX, a member of the Sa...
متن کاملThe molecular architecture of the sar locus in Staphylococcus aureus.
The global regulator sar in Staphylococcus aureus controls the synthesis of a variety of cell wall and extracellular proteins, many of which are putative virulence factors. The sar locus in strain RN6390 contains a 339-bp open reading frame (sarA) and an 860-bp upstream region. Transcriptional analyses of this locus revealed three different transcripts of 0.58, 0.84, and 1.15 kb (designated sar...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 84 7 شماره
صفحات -
تاریخ انتشار 2016